منابع مشابه
Resveratrol reduces myofibroblast arrhythmogenicity
Background Among grape skin polyphenols, trans-resveratrol (RES) has been reported to slow the development of cardiac fibrosis and to affect myofibroblast (MFB) differentiation. Because MFBs induce slow conduction and ectopic activity following heterocellular gap junctional coupling to cardiomyocytes, we investigated whether RES and its main metabolites affect arrhythmogenic cardiomyocyteMFB in...
متن کاملThe activated mesangial cell: a glomerular "myofibroblast"?
The glomerular mesangial cell may have several important beneficial functions in the normal glomerulus. These include the production of growth factors to allow normal cell turnover, the provision of structural support for the capillaries via the production of mesangial matrix, and the modulation of glomerular hemodynamics via their contractile properties. However, in various types of glomerular...
متن کاملMolecular regulation of myofibroblast formation
Novel strategies are required to counteract tissue contractures characteristic for organ fibrosis, stroma reaction to tumors, host reaction to implants, and formation of hypertrophic scars as after burns. Key element for the development and progression of these pathologies is the excessive contractile force generated by a-smooth muscle actin (a-SMA)-expressing myofibroblasts. We can modulate my...
متن کاملThe role of the myofibroblast in tumor stroma remodeling
Since its first description in wound granulation tissue, the myofibroblast has been recognized to be a key actor in the epithelial-mesenchymal cross-talk that plays a crucial role in many physiological and pathological situations, such as regulation of prostate development, ventilation-perfusion in lung alveoli or organ fibrosis. The presence of myofibroblasts in the stroma reaction to epitheli...
متن کاملThe fate of the primary cilium during myofibroblast transition
Myofibroblasts, the culprit of organ fibrosis, can originate from mesenchymal and epithelial precursors through fibroblast-myofibroblast and epithelial-myofibroblast transition (EMyT). Because certain ciliopathies are associated with fibrogenesis, we sought to explore the fate and potential role of the primary cilium during myofibroblast formation. Here we show that myofibroblast transition fro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2007
ISSN: 0002-9440
DOI: 10.2353/ajpath.2007.070112